The game crashes during gameplay and shows "Error _DOVK(): OUT OF MEMORY! ( vmaCreateBufferWithAlignment )". At the same time, GPU memory usage becomes very high. It looks like the game keeps increasing VRAM usage until it crashes. 

This should have been fixed in a hotfix recently. There was a UI batching GPU VRAM leak due to the most recent update.

store.steampowered.com

s&box - Hotfix 26.04.15a - Steam News

Fixed a VRAM leak with the new UI batching causing out of memory crashes